The role of B cells in acute and chronic infections

被引:39
作者
Bachmann, MF [1 ]
Kopf, M [1 ]
机构
[1] Basel Inst Immunol, CH-4005 Basel, Switzerland
关键词
D O I
10.1016/S0952-7915(99)80053-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The important role of B cells in protection against secondary viral infections has been recognized for a long time. Recent evidence suggests that B cells are also critically involved in protective immune reactions classically attributed to T cells. Specifically, antibodies have been documented to protect from many primary viral and parasitic infections and to be indispensable for the control of latent viral infections. Current vaccine strategies should take into account this pivotal role of antibodies.
引用
收藏
页码:332 / 339
页数:8
相关论文
共 73 条
  • [11] PROTECTION OF CHIMPANZEES FROM INFECTION BY HIV-1 AFTER VACCINATION WITH RECOMBINANT GLYCOPROTEIN GP120 BUT NOT GP160
    BERMAN, PW
    GREGORY, TJ
    RIDDLE, L
    NAKAMURA, GR
    CHAMPE, MA
    PORTER, JP
    WURM, FM
    HERSHBERG, RD
    COBB, EK
    EICHBERG, JW
    [J]. NATURE, 1990, 345 (6276) : 622 - 625
  • [12] BRENER Z, 1986, Parasitology Today, V2, P196, DOI 10.1016/0169-4758(86)90193-6
  • [13] Immunity to viruses in B cell-deficient mice: Influence of antibodies on virus persistence and on T cell memory
    Brundler, MA
    Aichele, P
    Bachmann, M
    Kitamura, D
    Rajewsky, K
    Zinkernagel, RM
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (09) : 2257 - 2262
  • [14] Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    Bull, PC
    Lowe, BS
    Kortok, M
    Molyneux, CS
    Newbold, CI
    Marsh, K
    [J]. NATURE MEDICINE, 1998, 4 (03) : 358 - 360
  • [15] Carroll MC, 1998, CURR OPIN IMMUNOL, V10, P36
  • [16] Antibody mediated protection against intracellular pathogens
    Casadevall, A
    [J]. TRENDS IN MICROBIOLOGY, 1998, 6 (03) : 102 - 107
  • [17] Cytotoxic T cells and viral hepatitis
    Chisari, FV
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (07) : 1472 - 1477
  • [18] IMPROVED IMMUNOGENICITY OF A PEPTIDE EPITOPE AFTER FUSION TO HEPATITIS-B CORE PROTEIN
    CLARKE, BE
    NEWTON, SE
    CARROLL, AR
    FRANCIS, MJ
    APPLEYARD, G
    SYRED, AD
    HIGHFIELD, PE
    ROWLANDS, DJ
    BROWN, F
    [J]. NATURE, 1987, 330 (6146) : 381 - 384
  • [19] Common themes of antibody maturation to simian immunodeficiency virus, simian-human immunodeficiency virus, and human immunodeficiency virus type 1 infections
    Cole, KS
    Murphey-Corb, M
    Narayan, O
    Joag, SV
    Shaw, GM
    Montelaro, RC
    [J]. JOURNAL OF VIROLOGY, 1998, 72 (10) : 7852 - 7859
  • [20] Deehan MR, 1998, J IMMUNOL, V160, P2692