Cytokines that regulate autoimmunity

被引：76

作者：

Diveu, Caroline ^{[1
]}

McGeachy, Mandy J. ^{[1
]}

Cua, Daniel J. ^{[1
]}

机构：

[1] Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 06期

关键词：

D O I：

10.1016/j.coi.2008.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGF beta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of ROR gamma-dependent Th17 cells. IL-23 - a member of the IL-12 family - activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when cysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 - another IL-12 family member - plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.

引用

页码：663 / 668

页数：6

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