SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips

被引：607

作者：

Maksimovic, Jovana ^{[1
]}

Gordon, Lavinia ^{[1
]}

Oshlack, Alicia ^{[1
]}

机构：

[1] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 06期

关键词：

GENOME-WIDE IDENTIFICATION; DNA METHYLATION; CPG ISLANDS; MICROARRAY; HYPERMETHYLATION; TECHNOLOGY; METHYLOMES; IDENTIFY; SCREEN; GENES;

D O I：

10.1186/gb-2012-13-6-r44

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA methylation is the most widely studied epigenetic mark and is known to be essential to normal development and frequently disrupted in disease. The Illumina HumanMethylation450 BeadChip assays the methylation status of CpGs at 485,577 sites across the genome. Here we present Subset-quantile Within Array Normalization (SWAN), a new method that substantially improves the results from this platform by reducing technical variation within and between arrays. SWAN is available in the minfi Bioconductor package.

引用

页数：12

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