Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine oxides by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis

被引：124

作者：

Harvey, James Stephen ^{[2
]}

Malcolmson, Steven J. ^{[1
]}

Dunne, Katherine S. ^{[2
]}

Meek, Simon J. ^{[1
]}

Thompson, Amber L. ^{[2
]}

Schrock, Richard R. ^{[3
]}

Hoveyda, Amir H. ^{[1
]}

Gouverneur, Veronique ^{[2
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

[2] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 04期

基金：

美国国家卫生研究院; 英国工程与自然科学研究理事会;

关键词：

enantioselective synthesis; homogeneous catalysis; molybdenum; olefin metathesis; phosphorus; NEUTRAL COORDINATE-ORGANOCATALYSTS; OLEFIN-METATHESIS; CROSS-METATHESIS; SECONDARY PHOSPHINES; ALKYLIDENE COMPLEXES; TERTIARY ETHERS; ALLYLATION; PHOSPHORUS; DESYMMETRIZATION; HETEROCYCLES;

D O I：

10.1002/anie.200805066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The first catalytic route toward the title compounds by asymmetric ring-closing metathesis is described. A remarkable reversal of enantioselectivity is observed when the achiral imido ligand of the chiral molybdenum-catalyst is changed (see scheme), thus highlighting the importance of the achiral and the chiral ligands in catalyst design. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：762 / 766

页数：5

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