Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?

被引：21

作者：

Guimaraes, Joana ^{[1
,2
]}

Moura, Eduardo ^{[2
,3
]}

Vieira-Coelho, Maria Augusta ^{[2
,3
]}

Garrett, Carolina ^{[1
,2
]}

机构：

[1] Univ Porto, Dept Neurol, Fac Med, Hosp Sao Joao, P-4200 Oporto, Portugal

[2] Inst Biol Mol & Celular, Oporto, Portugal

[3] Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Hosp Sao Joao, P-4200 Oporto, Portugal

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 09期

关键词：

Parkinson's disease; weight; deep brain modulation; noradrenergic modulation; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS ACTIVITY; BODY-WEIGHT; FOOD-INTAKE; ENERGY-EXPENDITURE; METABOLIC SYNDROME; NERVOUS-SYSTEM; ADIPOSE-TISSUE; GAIN; OBESITY;

D O I：

10.1002/mds.25063

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus. (c) 2012 Movement Disorder Society

引用

页码：1078 / 1082

页数：5

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