学术探索
学术期刊
新闻热点
数据分析
智能评审

Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?

被引：21
作者：
Guimaraes, Joana [1 ,2 ]
Moura, Eduardo [2 ,3 ]
Vieira-Coelho, Maria Augusta [2 ,3 ]
Garrett, Carolina [1 ,2 ]
机构：
[1] Univ Porto, Dept Neurol, Fac Med, Hosp Sao Joao, P-4200 Oporto, Portugal
[2] Inst Biol Mol & Celular, Oporto, Portugal
[3] Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Hosp Sao Joao, P-4200 Oporto, Portugal
来源：
MOVEMENT DISORDERS | 2012年 / 27卷 / 09期
关键词：
Parkinson's disease; weight; deep brain modulation; noradrenergic modulation; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS ACTIVITY; BODY-WEIGHT; FOOD-INTAKE; ENERGY-EXPENDITURE; METABOLIC SYNDROME; NERVOUS-SYSTEM; ADIPOSE-TISSUE; GAIN; OBESITY;
D O I：
10.1002/mds.25063
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus. (c) 2012 Movement Disorder Society
引用
收藏
页码：1078 / 1082
页数：5
相关论文
共 50 条
[21]   Neuropsychological and behavioral changes and weight gain after medial pallidotomy [J].
Lang, AE ;
Lozano, A ;
Tasker, R ;
Duff, J ;
SaintCyr, J ;
Trepanier, L .
ANNALS OF NEUROLOGY, 1997, 41 (06) :834-835
[22]  
LEIBOWITZ SF, 1982, BRAIN RES, V233, P97, DOI 10.1016/0006-8993(82)90933-7
[23]   INCREASED ENERGY-EXPENDITURE IN PARKINSONS-DISEASE [J].
LEVI, S ;
COX, M ;
LUGON, M ;
HODKINSON, M ;
TOMKINS, A .
BRITISH MEDICAL JOURNAL, 1990, 301 (6763) :1256-1257
[24]   Factors of importance for weight loss in elderly patients with Parkinson's disease [J].
Lorefält, B ;
Ganowiak, W ;
Pålhagen, S ;
Toss, G ;
Unosson, M ;
Granérus, AK .
ACTA NEUROLOGICA SCANDINAVICA, 2004, 110 (03) :180-187
[25]   Weight Loss, Body Fat Mass, and Leptin in Parkinson's Disease [J].
Lorefalt, Birgitta ;
Toss, Goran ;
Granerus, Ann-Kathrine .
MOVEMENT DISORDERS, 2009, 24 (06) :885-890
[26]   Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight [J].
Macia, F ;
Perlemoine, C ;
Coman, I ;
Guehl, D ;
Burbaud, P ;
Cuny, E ;
Gin, H ;
Rigalleau, V ;
Tison, F .
MOVEMENT DISORDERS, 2004, 19 (02) :206-212
[27]   Noradrenergic mechanisms in neurodegenerative diseases: a theory [J].
Marien, MR ;
Colpaert, FC ;
Rosenquist, AC .
BRAIN RESEARCH REVIEWS, 2004, 45 (01) :38-78
[28]   Mechanisms of body weight gain in patients with Parkinson's disease after subthalamic stimulation [J].
Montaurier, C. ;
Morio, B. ;
Bannier, S. ;
Derost, P. ;
Arnaud, P. ;
Brandolini-Bunion, M. ;
Giraudet, C. ;
Boirie, Y. ;
Durif, F. .
BRAIN, 2007, 130 :1808-1818
[29]   Interconnections between the neuroendocrine hypothalamus and the central autonomic system [J].
Palkovits, M .
FRONTIERS IN NEUROENDOCRINOLOGY, 1999, 20 (04) :270-295
[30]   Effects of subthalamic nucleus deep brain stimulation and levodopa on energy production rate and substrate oxidation in Parkinson's disease [J].
Perlemoine, C ;
Macia, F ;
Tison, F ;
Coman, I ;
Guehl, D ;
Burbaud, P ;
Cuny, E ;
Baillet, L ;
Gin, H ;
Rigalleau, V .
BRITISH JOURNAL OF NUTRITION, 2005, 93 (02) :191-198
12345