Weight Loss, Body Fat Mass, and Leptin in Parkinson's Disease

被引：71

作者：

Lorefalt, Birgitta ^{[1
]}

Toss, Goran ^{[2
]}

Granerus, Ann-Kathrine ^{[3
]}

机构：

[1] Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Fac Hlth Sci, SE-58185 Linkoping, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Div Internal Med, SE-58185 Linkoping, Sweden

[3] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Geriatr, SE-58185 Linkoping, Sweden

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 06期

关键词：

Parkinson's disease; body weight; body fat mass; leptin; ELDERLY-PATIENTS;

D O I：

10.1002/mds.22466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Weight loss is a common problem in Parkinson's disease (PD), but the causative mechanisms behind this weight loss are unclear. We compared 2( PD patients with sex and age matched healthy controls. Examinations were repeated at baseline, after one and after two years. Body fat mass was measured by Dual X-ray Absorptiometry (DXA). Seventy three per cent of the PD patients lost body weight. Loss of body fat mass constituted a considerable part of the loss of body weight. In the patients who lost weight, serum leptin levels were lower than in those who did not lose weight. The relationship between low body fat mass and low leptin levels seems to be relevant, at least for female PD patients. It is reasonable to believe that low leptin levels in these patients could be secondary to the decreased body fat mass. (C) 2009 Movement Disorder Society

引用

页码：885 / 890

页数：6

共 15 条

[1] Weight loss in Parkinson's disease [J].

Chen, HL ;

Zhang, SMM ;

Hernán, MA ;

Willett, WC ;

Ascherio, A .

ANNALS OF NEUROLOGY, 2003, 53 (05) :676-679

[2] Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss [J].

Evidente, VGH ;

Caviness, JN ;

Adler, CH ;

Gwinn-Hardy, KA ;

Pratley, RE .

MOVEMENT DISORDERS, 2001, 16 (05) :924-927

[3]

Fahn S., 1987, RECENT DEV PARKINSON, V2, P293, DOI DOI 10.2490/JJRMC.47.791

[4] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[5] Leptin and aging:: Correlation with endocrine changes in male and female healthy adult populations of different body weights [J].

Isidori, AM ;

Strollo, F ;

Morè, M ;

Caprio, M ;

Aversa, A ;

Moretti, C ;

Frajese, G ;

Riondino, G ;

Fabbri, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (05) :1954-1962

[6] Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women [J].

Kok, Petra ;

Roelfsema, Ferdinand ;

Frolich, Marijke ;

van Pelt, Johannes ;

Meinders, A. Edo ;

Pijl, Hanno .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (08) :3236-3240

[7] Food habits and intake of nutrients in elderly patients with Parkinson's disease [J].

Loewdalt, B ;

Ganowiak, W ;

Wissing, U ;

Granérus, AK ;

Unosson, M .

GERONTOLOGY, 2006, 52 (03) :160-168

[8] Factors of importance for weight loss in elderly patients with Parkinson's disease [J].

Lorefält, B ;

Ganowiak, W ;

Pålhagen, S ;

Toss, G ;

Unosson, M ;

Granérus, AK .

ACTA NEUROLOGICA SCANDINAVICA, 2004, 110 (03) :180-187

[9] INCREASED PREVALENCE OF UNDERNUTRITION IN PARKINSONS-DISEASE AND ITS RELATIONSHIP TO CLINICAL-DISEASE PARAMETERS [J].

MARKUS, HS ;

TOMKINS, AM ;

STERN, GM .

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1993, 5 (02) :117-125

[10] Mechanisms of body weight gain in patients with Parkinson's disease after subthalamic stimulation [J].

Montaurier, C. ;

Morio, B. ;

Bannier, S. ;

Derost, P. ;

Arnaud, P. ;

Brandolini-Bunion, M. ;

Giraudet, C. ;

Boirie, Y. ;

Durif, F. .

BRAIN, 2007, 130 :1808-1818

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