Mucins in the mucosal barrier to infection

被引:877
作者
Linden, S. K. [1 ]
Sutton, P. [2 ]
Karlsson, N. G. [3 ]
Korolik, V. [4 ]
McGuckin, M. A. [1 ]
机构
[1] Univ Queensland, Mater Hosp, Mucosal Dis Program, Mater Med Res Inst, Brisbane, Qld, Australia
[2] Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Melbourne, Vic, Australia
[3] Natl Univ Ireland, Dept Chem, Ctr Bioanalyt Sci, Galway, Ireland
[4] Griffith Univ, Inst Glyc, Gold Coast, Qld, Australia
关键词
D O I
10.1038/mi.2008.5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that cause human disease. Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia. In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive immunity and mucins, and the strategies used by successful mucosal pathogens to subvert or avoid the mucin barrier, with a particular focus on bacteria.
引用
收藏
页码:183 / 197
页数:15
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