lincRNAs: Genomics, Evolution, and Mechanisms

被引：2183

作者：

Ulitsky, Igor ^{[1
,2
,3
]}

Bartel, David P. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL | 2013年 / 154卷 / 01期

关键词：

LONG NONCODING RNA; PROTEIN-CODING GENE; X-CHROMOSOME INACTIVATION; XIST GENE; COMPUTATIONAL IDENTIFICATION; TRANSCRIPTIONAL NOISE; ACTIVE CHROMATIN; WIDE ANALYSIS; REVEALS; EXPRESSION;

D O I：

10.1016/j.cell.2013.06.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.

引用

页码：26 / 46

页数：21

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