A ligand-library approach to the highly efficient rhodium/phosphoramidite-catalyzed asymmetric arylation of N,N-dimethyl-sulfamoyl-protected aldimines

被引：156

作者：

Jagt, RBC ^{[1
]}

Toullec, PY ^{[1
]}

Geerdink, D ^{[1
]}

de Vries, JG ^{[1
]}

Feringa, BL ^{[1
]}

Minnaard, ADJ ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 17期

关键词：

arylation; arylboronic acids; asymmetric catalysis; diarylmethylamines; phosphoramiditesy;

D O I：

10.1002/anie.200504309

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Small but effective: The title reaction, after microwave-assisted removal of the N,N-dimethylsulfamoyl protecting group, leads to chiral diarylmethyl amines. The use of 1 mol% catalyst and 1.3 equivalents of aryl boronic acid results in excellent yields (up to 98%) and enantioselectivities (up to 95% ee) of the isolated products. acac = acetylacetonate; eth = ethylene. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2789 / 2791

页数：3

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