Solubility of nicotinic acid in polyamidoamine dendrimer solutions

被引：49

作者：

Cheng, YY ^{[1
]}

Xu, TW

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Struct Biol Lab, Dept Polymer Sci & Engn, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 12期

关键词：

polyamidoamine dendrimers; PAMAM; solubility enhancer; nicotinic acid;

D O I：

10.1016/j.ejmech.2005.08.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study we investigated the effect of ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers on the aqueous solubility of nicotinic acid. The aqueous solubility of nicotinic acid was measured in the presence of dendrimers at room temperature in distilled water. The effect of variables, such as pH condition, concentration, surface functional group and generation (molecule size) of dendrimer, has been investigated. Results showed that the solubility of nicotinic acid in the dendrimer solutions was proportional to dendrimer concentration, both amine and ester-terminated dendrimers caused the higher increase in nicotinic acid solubility at higher pH conditions. The order in which the dendrimers increased the solubility at a constant pH condition was G4 > G3 > G2 > G1. In addition, at each pH, the solubility of nicotinic acid was greater in the presence of amine-terminated dendrimers compared to the amine ester-terminated dendrimers possessing the same number of surface functional groups. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of nicotinic acid. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：1384 / 1389

页数：6

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