The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system

被引：18

作者：

Hamada, T ^{[1
]}

Ui-Tei, K

Imaki, J

Takahashi, F

Onodera, H

Mishima, T

Miyata, Y

机构：

[1] Nippon Med Coll, Dept Pharmacol, Bunkyo Ku, Tokyo 1138602, Japan

[2] Nippon Med Coll, Dept Anat, Bunkyo Ku, Tokyo 1138602, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 112卷 / 1-2期

关键词：

spinal cord-derived growth factor/platelet-derived growth factor-C/fallotein; spinal cord-derived growth factor-B/platelet-derived growth factor-D; central nervous system; spinal cord; motoneuron; floor plate;

D O I：

10.1016/S0925-4773(01)00625-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examined the expression patterns of the two homologous genes, spinal cord-derived growth factor (SCDGF)platelet-derived growth factor (PDGF)-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. In the spinal cord, SCDGF/PDGF-C/fallotein was expressed in the floor plate at embryonic day (E) 11 and also in the ventricular zone at E16 but not in adult. However, SCDGF-B/PDGF-D was prominently expressed in the adult motoneurons, although faint expression was observed in the ventral ventricular zone at E16. Also in the brain, the expression of SCDGF/PDGF-C/fallotein was more remarkable at E16 than at adult. It was highly expressed in the cortex, pontine area and choroid plexus at E16. Contrary to SCDGF/PDGF-C/fallotein, SCDGF-B/PDGF-D expression was notable in several nuclei at adult. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 164

页数：4

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