Towards nucleopeptides containing any trifunctional amino acid

被引：33

作者：

Robles, J ^{[1
]}

Beltrán, M ^{[1
]}

Marchán, V ^{[1
]}

Pérez, Y ^{[1
]}

Travesset, I ^{[1
]}

Pedroso, E ^{[1
]}

Grandas, A ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

TETRAHEDRON | 1999年 / 55卷 / 46期

关键词：

D O I：

10.1016/S0040-4020(99)00815-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleopeptides incorporating, besides the linking residue, other trifunctional amino acids such as lysine, arginine, tryptophan, serine, threonine and tyrosine have been obtained following stepwise solid-phase assembly. The best alternatives for the protection of the side chains of these trifunctional amino acids are discussed. The use of different solid supports (polystyrene-co-1%-divinylbenzene, controlled pore glass and polyethylene glycol-polystyrene) and nucleopeptide-resin linkers has also been evaluated. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：13251 / 13264

页数：14

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