The synthesis of a novel benzodiazocine via an intramolecular Staudinger/Aza-Wittig cyclization

被引：29

作者：

ONeil, IA ^{[1
]}

Murray, CL ^{[1
]}

Potter, AJ ^{[1
]}

Kalindjian, SB ^{[1
]}

机构：

[1] JAMES BLACK FDN,LONDON SE24 9JE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)00680-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel pyrrolobenzodiazocine (1) has been prepared by an intramolecular Staudinger/aza Wittig protocol from the precursor azido aldehyde (2) in a remarkable 93% yield. Aldehyde (2) was prepared by coupling protected homoprolinol with 2-azidobenzoic acid followed by deprotection and oxidation. (C) 1997 Elsevier Science Ltd.

引用

页码：3609 / 3610

页数：2

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[2]

EGUCHI S, 1995, J ORG CHEM, V60, P4026

[3]

JOHNSON AW, 1993, YLIDES IMINES PHOSPH

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