Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via azido reductive cyclization with HMDST

被引：42

作者：

Kamal, A

Reddy, BSP

Reddy, BSN

机构：

[1] Division of Organic Chemistry, Indian Inst. of Chemical Technology

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(96)01484-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new facile synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) ring system has been achieved by reductive cyclization of the azide employing hexamethyldisilathiane (HMDST). The parent unsubstituted PBD and the natural product DC-81 have also been prepared in good overall yields. Copyright (C) 1996 Published by Elsevier Science Ltd

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页码：6803 / 6806

页数：4

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