A new facile procedure for the preparation of pyrrolo[2,1-c] [1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

被引：31

作者：

Kamal, A

Reddy, BSP

Reddy, BSN

机构：

[1] Division of Organic Chemistry, Indian Inst. of Chemical Technology

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 13期

关键词：

D O I：

10.1016/0040-4039(96)00243-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the imine form of the pyrrolo[2,1-c] [1,4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81(5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.

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页码：2281 / 2284

页数：4

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