Cancer related inflammation: The macrophage connection

被引：462

作者：

Sica, Antonio

Allavena, Paola ^{[1
]}

Mantovani, Alberto ^{[1
,2
]}

机构：

[1] Fdn Humanitas Ric, Ist Clin Humanitas, I-20089 Milan, Italy

[2] Univ Milan, I-20133 Milan, Italy

来源：

CANCER LETTERS | 2008年 / 267卷 / 02期

关键词：

tumor-associated macrophages; macrophage polarization; tumour promotion; therapeutic targets; inflammation; cancer; chemokines; cytokines; angiogenesis;

D O I：

10.1016/j.canlet.2008.03.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases. promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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页码：204 / 215

页数：12

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