1,2 asymmetric induction in the TiCl4 mediated alkylation of alpha-methyl-beta-silyloxy ketones with Grignard reagents.

被引：9

作者：

Bartoli, G ^{[1
]}

Bosco, M ^{[1
]}

Sambri, L ^{[1
]}

Marcantoni, E ^{[1
]}

机构：

[1] UNIV CAMERINO,DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,MC,ITALY

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 21期

关键词：

ADDITION-REACTIONS; DIASTEREOSELECTIVE REDUCTION; 1,3-ASYMMETRIC INDUCTION; CHELATION CONTROL; HYDROXY KETONES; ALDEHYDES; ORGANOMETALLICS; PROTOCOL; OXIDES;

D O I：

10.1016/S0040-4039(97)00735-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transmetallation of an alpha-methyl-beta-silyloxy ketone with TiCl4 in toluene affords a cyclic chelation complex which undergoes highly stereoselective alkylation from Grignard reagents at the less hindered side. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：3785 / 3788

页数：4

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