Early nonsense: mRNA decay solves a translational problem

被引:221
作者
Amrani, Nadia
Sachs, Matthew S.
Jacobson, Allan [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01655 USA
[2] Oregon Hlth & Sci Univ, Dept Environm & Biomol Syst, Beaverton, OR 97006 USA
[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA
关键词
D O I
10.1038/nrm1942
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination - or nonsense - codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolve a poorly dissociable termination complex.
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页码:415 / 425
页数:11
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