Pathogenetic mechanisms in thyroid follicular-cell neoplasia

被引:695
作者
Kondo, T
Ezzat, S
Asa, SL [1 ]
机构
[1] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Dept Pathol, Toronto Med Labs, Toronto, ON M5G 2C4, Canada
[3] Univ Toronto, Toronto Med Labs, Toronto, ON M5G 2C4, Canada
[4] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON M5G 2C4, Canada
[5] Freeman Ctr Endocrine Oncol, Toronto, ON M5G 2M9, Canada
[6] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[7] Mt Sinai Hosp, Dept Med, Toronto, ON M5G 1X5, Canada
[8] Univ Toronto, Toronto, ON M5G 1X5, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1038/nrc1836
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
引用
收藏
页码:292 / 306
页数:15
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