Pathogenetic mechanisms in thyroid follicular-cell neoplasia

被引:695
作者
Kondo, T
Ezzat, S
Asa, SL [1 ]
机构
[1] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Dept Pathol, Toronto Med Labs, Toronto, ON M5G 2C4, Canada
[3] Univ Toronto, Toronto Med Labs, Toronto, ON M5G 2C4, Canada
[4] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON M5G 2C4, Canada
[5] Freeman Ctr Endocrine Oncol, Toronto, ON M5G 2M9, Canada
[6] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[7] Mt Sinai Hosp, Dept Med, Toronto, ON M5G 1X5, Canada
[8] Univ Toronto, Toronto, ON M5G 1X5, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1038/nrc1836
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
引用
收藏
页码:292 / 306
页数:15
相关论文
共 235 条
[31]   Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer [J].
Cheung, CC ;
Carydis, B ;
Ezzat, S ;
Bedard, YC ;
Asa, SL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (05) :2187-2190
[32]   Immunohistochemical diagnosis of papillary thyroid carcinoma [J].
Cheung, CC ;
Ezzat, S ;
Freeman, JL ;
Rosen, IB ;
Asa, SL .
MODERN PATHOLOGY, 2001, 14 (04) :338-342
[33]   Detection of the PAX8-PPARγ fusion oncogene in both follicular thyroid carcinomas and adenomas [J].
Cheung, L ;
Messina, M ;
Gill, A ;
Clarkson, A ;
Learoyd, D ;
Delbridge, L ;
Wentworth, J ;
Philips, J ;
Clifton-Bligh, R ;
Robinson, BG .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :354-357
[34]   The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions [J].
Chiappetta, G ;
Toti, P ;
Cetta, F ;
Giuliano, A ;
Pentimalli, F ;
Amendola, I ;
Lazzi, S ;
Monaco, M ;
Mazzuchelli, L ;
Tosi, P ;
Santoro, M ;
Fusco, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :364-369
[35]   Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer [J].
Ciampi, R ;
Knauf, JA ;
Kerler, R ;
Gandhi, M ;
Zhu, ZW ;
Nikiforova, MN ;
Rabes, HM ;
Fagin, JA ;
Nikiforov, YE .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (01) :94-101
[36]   ANALYSIS OF ADENOMATOUS POLYPOSIS-COLI GENE IN THYROID-TUMORS [J].
COLLETTA, G ;
SCIACCHITANO, S ;
PALMIROTTA, R ;
RANIERI, A ;
ZANELLA, E ;
CAMA, A ;
COSTANTINI, RM ;
BATTISTA, P ;
PONTECORVI, A .
BRITISH JOURNAL OF CANCER, 1994, 70 (06) :1085-1088
[37]   Thyroid carcinoma in the McCune-Albright syndrome:: Contributory role of activating Gsα mutations [J].
Collins, MT ;
Sarlis, NJ ;
Merino, MJ ;
Monroe, J ;
Crawford, SE ;
Krakoff, JA ;
Guthrie, LC ;
Bonat, S ;
Robey, PG ;
Shenker, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (09) :4413-4417
[38]   Frequent RET rearrangements in thyroid papillary microcarcinoma detected by interphase fluorescence in situ hybridization [J].
Corvi, R ;
Martinez-Alfaro, M ;
Harach, HR ;
Zini, M ;
Papotti, M ;
Romeo, G .
LABORATORY INVESTIGATION, 2001, 81 (12) :1639-1645
[39]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[40]  
De Moerlooze L, 2000, DEVELOPMENT, V127, P483