Preparation of active esters on solid support for aqueous-phase peptide couplings

被引：17

作者：

Corbett, AD ^{[1
]}

Gleason, JL ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(01)02389-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TentaGel supported active esters analogous to those prepared from solution-phase 1-hydroxybenzotriazole. N-hydroxysuccinimide and pentafluorophenol were prepared and examined for their ability to effect aqueous-phase peptide couplings. HOBt esters showed high hydrolysis rates, relative to peptide coupling. while active esters derived from 4-hydroxy-2.3.5.6-tetrafluorobenzoic acid produced mainly dipeptide coupling products when treated with amino acids in water. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1369 / 1372

页数：4

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