Natural killer cells in human health and disease

被引：213

作者：

Orange, JS

Ballas, ZK ^{[1
]}

机构：

[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City VA Med Ctr,Div Allergy & Immunol, Iowa City, IA 52242 USA

[2] Univ Penn, Sch Med, Dept Pediat, Childrens Hosp Philadelphia,Div Allergy & Immunol, Philadelphia, PA 19104 USA

来源：

CLINICAL IMMUNOLOGY | 2006年 / 118卷 / 01期

关键词：

natural killer cells; innate immunity; cytotoxicity; killer cell immunoglobulin-like receptors; immunodeficiency;

D O I：

10.1016/j.clim.2005.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host defense and immune regulation. They are activated or inhibited through the ligation of germline-encoded receptors and are involved in mediating cytotoxicity, in producing cytokines and in providing co-stimulation to cells of the adaptive immune system. NK cells play important roles in viral infections, autoimmunity, pregnancy, cancer and bone marrow transplantation. This review highlights recent developments in the understanding of the role of human NK cells in health and disease. Published by Elsevier Inc.

引用

页码：1 / 10

页数：10

共 93 条

[51] Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells [J].

Mandelboim, O ;

Lieberman, N ;

Lev, M ;

Paul, L ;

Arnon, TI ;

Bushkin, Y ;

Davis, DM ;

Strominger, JL ;

Yewdell, JW ;

Porgador, A .

NATURE, 2001, 409 (6823) :1055-1060

[52]

Martin MP, 2002, NAT GENET, V31, P429, DOI 10.1038/ng934

[53] Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer [J].

Miller, JS ;

Soignier, Y ;

Panoskaltsis-Mortari, A ;

McNearney, SA ;

Yun, GH ;

Fautsch, SK ;

McKenna, D ;

Le, C ;

Defor, TE ;

Burns, LJ ;

Orchard, PJ ;

Blazar, BR ;

Wagner, JE ;

Slungaard, A ;

Weisdorf, DJ ;

Okazaki, IJ ;

McGlave, PB .

BLOOD, 2005, 105 (08) :3051-3057

[54] Association of killer cell immunoglobulin-like receptors with scleroderma [J].

Momot, T ;

Koch, S ;

Hunzelmann, N ;

Krieg, T ;

Ulbricht, K ;

Schmidt, RE ;

Witte, T .

ARTHRITIS AND RHEUMATISM, 2004, 50 (05) :1561-1565

[55] P58 MOLECULES AS PUTATIVE RECEPTORS FOR MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-I MOLECULES IN HUMAN NATURAL-KILLER (NK) CELLS - ANTI-P58 ANTIBODIES RECONSTITUTE LYSIS OF MHC CLASS-I-PROTECTED CELLS IN NK CLONES DISPLAYING DIFFERENT SPECIFICITIES [J].

MORETTA, A ;

VITALE, M ;

BOTTINO, C ;

ORENGO, AM ;

MORELLI, L ;

AUGUGLIARO, R ;

BARBARESI, M ;

CICCONE, E ;

MORETTA, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :597-604

[56] Trafficking of Natural Killer Cells [J].

Morris, MA ;

Ley, K .

CURRENT MOLECULAR MEDICINE, 2004, 4 (04) :431-438

[57] Cutting edge: Heterozygote advantage in autoimmune disease: Hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis [J].

Nelson, GW ;

Martin, MP ;

Gladman, D ;

Wade, J ;

Trowsdale, J ;

Carrington, M .

JOURNAL OF IMMUNOLOGY, 2004, 173 (07) :4273-4276

[58] Of genes and phenotypes:: the immunological and molecular spectrum of combined immune deficiency.: Defects of the γc-JAK3 signaling pathway as a model [J].

Notarangelo, LD ;

Giliani, S ;

Mazza, C ;

Mella, P ;

Savoldi, G ;

Rodriguez-Pérez, C ;

Mazzolari, E ;

Fiorini, M ;

Duse, M ;

Plebani, A ;

Ugazio, AG ;

Vihinen, M ;

Candotti, F ;

Schumacher, RF .

IMMUNOLOGICAL REVIEWS, 2000, 178 :39-48

[59] Human natural killer cell deficiencies and susceptibility to infection [J].

Orange, JS .

MICROBES AND INFECTION, 2002, 4 (15) :1545-1558

[60] Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations [J].

Orange, JS ;

Brodeur, SR ;

Jain, A ;

Bonilla, FA ;

Schneider, LC ;

Kretschmer, R ;

Nurko, S ;

Rasmussen, WL ;

Köhler, JR ;

Gellis, SE ;

Ferguson, BM ;

Strominger, JL ;

Zonana, J ;

Ramesh, N ;

Ballas, ZK ;

Geha, RS .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (11) :1501-1509

← 1 2 3 4 5 6 7 8 9 10 →