Tools to therapeutically harness the human antibody response

被引：97

作者：

Wilson, Patrick C. ^{[1
,2
]}

Andrews, Sarah F. ^{[1
]}

机构：

[1] Univ Chicago, Dept Med Rheumatol, Chicago, IL 60637 USA

[2] Univ Chicago, Knapp Ctr Lupus & Immunol Res, Comm Immunol, Chicago, IL 60637 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HUMAN MONOCLONAL-ANTIBODIES; MEMORY B-CELLS; NEUTRALIZING ANTIBODIES; DENGUE VIRUS; INFLUENZA VACCINE; RAPID GENERATION; HIV-ANTIBODIES; PLASMA-CELLS; BROAD; POTENT;

D O I：

10.1038/nri3285

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The natural human antibody response is a rich source of highly specific, neutralizing and self-tolerant therapeutic reagents. Recent advances have been made in isolating and characterizing monoclonal antibodies that are generated in response to natural infection or vaccination. Studies of the human antibody response have led to the discovery of crucial epitopes that could serve as new targets in vaccine design and in the creation of potentially powerful immunotherapies. With a focus on influenza virus and HIV, herein we summarize the technological tools used to identify and characterize human monoclonal antibodies and describe how these tools might be used to fight infectious diseases.

引用

页码：709 / 719

页数：11

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