Development of analytical methods for multiresidue determination of quinolones in pig muscle samples by liquid chromatography with ultraviolet detection, liquid chromatography-mass spectrometry and liquid chromagraphy-tandem mass spectrometry

被引：72

作者：

Hermo, MP ^{[1
]}

Barrón, D ^{[1
]}

Barbosa, J ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2006年 / 1104卷 / 1-2期

关键词：

liquid chromatography; mass spectrometry; pig muscle; quinolones;

D O I：

10.1016/j.chroma.2005.11.080

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents a comparison between liquid chromatography with ultraviolet detection (LC-UV), liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods developed for the multiresidue determination of 8 quinolones, around their maximum residue levels (MRLs) in pig muscle. The procedure involves common extraction of the quinolones from the tissues by traditional extraction, a step for clean-up and preconcentration of the analytes by solid-phase extraction (SPE) and a subsequent liquid chromatographic analysis. The methods present satisfactory results of linearity, precision and limits of quantification much lower than the MRLs established by the European Union for quinolones in pig tissues. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：132 / 139

页数：8

共 23 条

[1]

[Anonymous], 2001, Guidance for industry, bioanalytical method validation

[2] Determination of quinolones in chicken tissues by liquid chromatography with ultraviolet absorbance detection [J].

Bailac, S ;

Ballesteros, O ;

Jiménez-Lozano, E ;

Barrón, D ;

Sanz-Nebot, V ;

Navalón, A ;

Vílchez, JL ;

Barbosa, J .

JOURNAL OF CHROMATOGRAPHY A, 2004, 1029 (1-2) :145-151

[3]

BAILAC S, IN PRESS J SEP SCI

[4] Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry [J].

Balizs, G ;

Hewitt, A .

ANALYTICA CHIMICA ACTA, 2003, 492 (1-2) :105-131

[5] The application of factor analysis to solvatochromic parameters and pHs values for the standardization of potentiometric sensors in mobile phases used in liquid chromatography [J].

Barbosa, J ;

Marqués, I ;

Barrón, D ;

Sanz-Nebot, V .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 1999, 18 (08) :543-549

[6] Analysis of fluoroquinolones in biological fluids by high-performance liquid chromatography [J].

Carlucci, G .

JOURNAL OF CHROMATOGRAPHY A, 1998, 812 (1-2) :343-367

[7]

*COMM EUR COMM, COMM DEC 2002 657 EC

[8] Liquid chromatographic-mass spectrometric methods for analyzing antibiotic and antibacterial agents in animal food products [J].

Di Corcia, A ;

Nazzari, M .

JOURNAL OF CHROMATOGRAPHY A, 2002, 974 (1-2) :53-89

[9] Determination of residues of quinolones in pig muscle comparative study of classical and microwave extraction techniques [J].

Hermo, MP ;

Barrón, D ;

Barbosa, J .

ANALYTICA CHIMICA ACTA, 2005, 539 (1-2) :77-82

[10] Analysis of quinolone residues in edible animal products [J].

Hernández-Arteseros, JA ;

Barbosa, J ;

Compañó, R ;

Prat, MD .

JOURNAL OF CHROMATOGRAPHY A, 2002, 945 (1-2) :1-24

← 1 2 3 →