Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma

被引:108
作者
Haefliger, IO [1 ]
Dettmann, E [1 ]
Liu, R [1 ]
Meyer, P [1 ]
Prünte, C [1 ]
Messerli, J [1 ]
Flammer, J [1 ]
机构
[1] Univ Basel, Eye Clin, Lab Ocular Pharmacol & Physiol, CH-4012 Basel, Switzerland
关键词
choroid; endothelin; endothelium-derived contracting factor; endothelium-derived relaxing factor; nitric oxide; nitric oxide synthase; normal-tension glaucoma; retina; trabecular meshwork; vasospasm;
D O I
10.1016/S0039-6257(99)00026-0
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Glaucoma is an optic nerve head neuropathy in which retinal ganglion cells are lost. A clear association exists between glaucoma and different risk factors, such as high intraocular pressure (IOP) or blood-flow dysregulation. Nitric oxide (NO) and endothelin, two recently identified cellular mediators, appear to be involved in the regulation of IOP as well as in the modulation of ocular blood flow. To some extent, NO is also involved in apoptosis, a mechanism of cell death that can lead to retinal ganglion cell loss in glaucoma. This article provides a short and simplified overview of the biochemistry of NO and endothelin and highlights the potential role of these two mediators in certain important aspects related to the pathogenesis of glaucoma. (C) 1999 by Elsevier Science Inc. All rights reserved.
引用
收藏
页码:S51 / S58
页数:8
相关论文
共 81 条
  • [1] Nitric oxide and peroxynitrite production in ocular inflammation
    Allen, JB
    Keng, T
    Privalle, C
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 : 1145 - 1149
  • [2] SRTX-D, A NEW NATIVE PEPTIDE OF THE ENDOTHELIN SARAFOTOXIN FAMILY
    BDOLAH, A
    WOLLBERG, Z
    FLEMINGER, G
    KOCHVA, E
    [J]. FEBS LETTERS, 1989, 256 (1-2) : 1 - 3
  • [3] Nitric oxide in the eye: Multifaceted roles and diverse outcomes
    Becquet, F
    Courtois, Y
    Goureau, O
    [J]. SURVEY OF OPHTHALMOLOGY, 1997, 42 (01) : 71 - 82
  • [4] BeharCohen FF, 1996, INVEST OPHTH VIS SCI, V37, P1711
  • [5] APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES
    BONFOCO, E
    KRAINC, D
    ANKARCRONA, M
    NICOTERA, P
    LIPTON, SA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) : 7162 - 7166
  • [6] Bonne C, 1996, J FR OPHTALMOL, V19, P69
  • [7] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER
    BREDT, DS
    SNYDER, SH
    [J]. NEURON, 1992, 8 (01) : 3 - 11
  • [8] Nitric oxide and its role in apoptosis
    Brüne, B
    von Knethen, A
    Sandau, KB
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 351 (03) : 261 - 272
  • [9] Brune B, 1998, BIOCHEMISTRY-MOSCOW+, V63, P817
  • [10] THE ROLE OF NITRIC-OXIDE AND OTHER ENDOTHELIUM-DERIVED VASOACTIVE SUBSTANCES IN VASCULAR-DISEASE
    COHEN, RA
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 1995, 38 (02) : 105 - 128