Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

被引：193

作者：

Kim, Dae-Hyeong ^{[2
]}

Ghaffari, Roozbeh ^{[4
]}

Lu, Nanshu ^{[3
]}

Wang, Shuodao ^{[5
,6
]}

Lee, Stephen P. ^{[4
]}

Keum, Hohyun ^{[1
]}

D'Angelo, Robert ^{[4
]}

Klinker, Lauren ^{[4
]}

Su, Yewang ^{[5
,6
,7
]}

Lu, Chaofeng ^{[5
,6
,8
,9
]}

Kim, Yun-Soung ^{[1
]}

Ameen, Abid ^{[1
]}

Li, Yuhang ^{[5
,6
,10
]}

Zhang, Yihui ^{[5
,6
,7
]}

de Graff, Bassel ^{[4
]}

Hsu, Yung-Yu ^{[4
]}

Liu, ZhuangJian ^{[11
]}

Ruskin, Jeremy ^{[12
]}

Xu, Lizhi ^{[1
]}

Lu, Chi ^{[1
]}

Omenetto, Fiorenzo G. ^{[13
]}

Huang, Yonggang ^{[5
,6
]}

Mansour, Moussa ^{[12
]}

Slepian, Marvin J. ^{[14
,15
]}

Rogers, John A. ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Seoul Natl Univ, Sch Chem & Biol Engn, World Class Univ Program Chem Convergence Energy, Inst Basic Sci,Ctr Nanoparticle Res, Seoul 151742, South Korea

[3] Univ Texas Austin, Dept Aerosp Engn & Engn Mech, Austin, TX 78712 USA

[4] MC10 Inc, Cambridge, MA 02140 USA

[5] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[6] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA

[7] Tsinghua Univ, Ctr Mech & Mat, Beijing 100084, Peoples R China

[8] Zhejiang Univ, Soft Matter Res Ctr, Hangzhou 310058, Zhejiang, Peoples R China

[9] Zhejiang Univ, Dept Civil Engn, Hangzhou 310058, Zhejiang, Peoples R China

[10] Harbin Inst Technol, Sch Astronaut, Harbin 150001, Peoples R China

[11] ASTAR, Inst High Performance Comp, Singapore 138632, Singapore

[12] Massachusetts Gen Hosp, Cardiac Arrhythmia Unit, Boston, MA 02140 USA

[13] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[14] Univ Arizona, Sarver Heart Ctr, Dept Med, Tucson, AZ 85724 USA

[15] Univ Arizona, Sarver Heart Ctr, Dept Biomed Engn, Tucson, AZ 85724 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 49期

基金：

新加坡国家研究基金会;

关键词：

flexible electronics; semiconductor nanomaterials; stretchable electronics; implantable biomedical devices; cardiac electrophysiology; PERSISTENT ATRIAL-FIBRILLATION; CATHETER ABLATION; EPICARDIAL ACTIVATION; SOCK ELECTRODE; HEART; ELECTROPHYSIOLOGY; ELECTROGONIOMETER; MECHANISMS; ISLANDS; ARRAY;

D O I：

10.1073/pnas.1205923109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, non-constraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.

引用

页码：19910 / 19915

页数：6

共 55 条

[1] 256-Channel Neural Recording and Delta Compression Microsystem With 3D Electrodes [J].