Regulation of superoxide production in neutrophils: role of calcium influx

被引:153
作者
Brechard, Sabrina [1 ]
Tschirhart, Eric J. [1 ]
机构
[1] Univ Luxembourg, Life Sci Res Unit, L-1511 Luxembourg, Luxembourg
关键词
store-operated Ca2+ entry; NADPH oxidase; granulocytes;
D O I
10.1189/jlb.0807553
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Upon stimulation, activation of NADPH oxidase complexes in neutrophils produces a burst of superoxide anions contributing to oxidative stress and the development of inflammatory process. Store-operated calcium entry (SOCE), whereby the depletion of intracellular stores induces extracellular calcium influx, is known to be a crucial element of NADPH oxidase regulation. However, the mechanistic basis mediating SOCE is still only partially understood, as is the signal-coupling pathway leading to modulation of store-operated channels. This review emphasizes the role of calcium influx in the control of the NADPH oxidase and summarizes the current knowledge of pathways mediating this extracellular calcium entry in neutrophils. Such investigations into the cross-talk between NADPH oxidase and calcium might allow the identification of novel pharmacological targets with clinical use, particularly in inflammatory diseases. J. Leukoc. Biol. 84: 1223-1237; 2008.
引用
收藏
页码:1223 / 1237
页数:15
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