Regulatory B and T cells in infections

被引：47

作者：

Majlessi, Laleh ^{[1
,2
]}

Lo-Man, Richard ^{[1
,2
]}

Leclerc, Claude ^{[1
,2
]}

机构：

[1] Inst Pasteur, Unite Regulat Immunitaire & Vaccinol, F-75724 Paris 15, France

[2] Inst Natl Sante & Rech Med, U883, F-75724 Paris 15, France

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 09期

关键词：

Regulatory B and T; Infections; Immune modulation;

D O I：

10.1016/j.micinf.2008.07.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of T and B lymphocytes, as antigen-specific effector immune cells playing an essential role in host defense against pathogens. is well recognized. Over the last decade, these lymphocytes have however also emerged as key regulatory components of the immune system,, able to prevent various immunopathologies due to excessive inflammatory responses. These regulatory T (Treg) and B (Breg) cells. endowed with anti-inflammatory properties, operate via both antigen-specific and non-specific mechanisms and mainly develop during chronic infections. Here, we discuss the role of Treg and Breg lymphocytes in various infectious diseases, in experimental murine models and in human. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：1030 / 1035

页数：6

共 43 条

[1] The Xid defect imparts susceptibility to experimental murine filariosis - association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine [J].

Al-Qaoud, KM ;

Fleischer, B ;

Hoerauf, A .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (01) :17-25

[2] B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection [J].

Baumgarth, N ;

Herman, OC ;

Jager, GC ;

Brown, LE ;

Herzenberg, LA ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :271-280

[3] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[4] Regulatory T cells and infection: a dangerous necessity [J].

Belkaid, Yasmine .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (11) :875-888

[5] A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection [J].

Boes, M ;

Prodeus, AP ;

Schmidt, T ;

Carroll, MC ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2381-2386

[6] CD4+CD25+FoxP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease [J].

Chen, Xinchun ;

Zhou, Boping ;

Li, Meizhong ;

Deng, Qunyi ;

Wu, Xueqiong ;

Le, Xiaohua ;

Wu, Chi ;

Larmonier, Nicolas ;

Zhang, Wei ;

Zhang, Hongmei ;

Wang, Huosheng ;

Katsanis, Emmanuel .

CLINICAL IMMUNOLOGY, 2007, 123 (01) :50-59

[7] B cells regulate autoimmunity by provision of IL-10 [J].

Fillatreau, S ;

Sweenie, CH ;

McGeachy, MJ ;

Gray, D ;

Anderton, SM .

NATURE IMMUNOLOGY, 2002, 3 (10) :944-950

[8] X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model [J].

Gaubert, S ;

Da Costa, AV ;

Maurage, CA ;

Lima, ECS ;

Fontaine, J ;

Lafitte, S ;

Minoprio, P ;

Capron, A ;

Grzych, JM .

PARASITE IMMUNOLOGY, 1999, 21 (02) :89-101

[9] Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis [J].

Guyot-Revol, V ;

Innes, JA ;

Hackforth, S ;

Hinks, T ;

Lalvani, A .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (07) :803-810

[10] B cell development pathways [J].

Hardy, RR ;

Hayakawa, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :595-621

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