Transcriptional control of B-cell development

被引：119

作者：

Schebesta, M ^{[1
]}

Heavey, B ^{[1
]}

Busslinger, M ^{[1
]}

机构：

[1] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(02)00324-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Significant progress has recently been made in our understanding of how transcription factors such as PU.1, Notch1, E2A, EBF, Pax5, Bcl6, Blimp1 and XBP1 control different developmental decisions during the onset and terminal phase of B-lymphopoiesis. One emerging theme is that negative regulatory networks play an important role in suppressing alternative gene programs and their corresponding cell fates throughout B-cell development.

引用

页码：216 / 223

页数：8

共 68 条

[1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[2] Notch signaling in lymphocyte development [J].

Anderson, AC ;

Robey, EA ;

Huang, YH .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (05) :554-560

[3] Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo [J].

Angelin-Duclos, C ;

Cattoretti, G ;

Lin, KI ;

Calame, K .

JOURNAL OF IMMUNOLOGY, 2000, 165 (10) :5462-5471

[4] E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].

BAIN, G ;

MAANDAG, ECR ;

IZON, DJ ;

AMSEN, D ;

KRUISBEEK, AM ;

WEINTRAUB, BC ;

KROP, I ;

SCHLISSEL, MS ;

FEENEY, AJ ;

VANROON, M ;

VANDERVALK, M ;

TERIELE, HPJ ;

BERNS, A ;

MURRE, C .

CELL, 1994, 79 (05) :885-892

[5] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[6] Plasma cells: finding new light at the end of B cell development [J].

Calame, KL .

NATURE IMMUNOLOGY, 2001, 2 (12) :1103-1108

[7] IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J].

Calfon, M ;

Zeng, HQ ;

Urano, F ;

Till, JH ;

Hubbard, SR ;

Harding, HP ;

Clark, SG ;

Ron, D .

NATURE, 2002, 415 (6867) :92-96

[8] MUTATIONS OF THE INTRONIC IGH ENHANCER AND ITS FLANKING SEQUENCES DIFFERENTIALLY AFFECT ACCESSIBILITY OF THE J(H)-LOCUS [J].

CHEN, JZ ;

YOUNG, F ;

BOTTARO, A ;

STEWART, V ;

SMITH, RK ;

ALT, FW .

EMBO JOURNAL, 1993, 12 (12) :4635-4645

[9] BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage [J].

Chiang, MY ;

Monroe, JG .

BLOOD, 1999, 94 (11) :3621-3632

[10] PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors [J].

DeKoter, RP ;

Walsh, JC ;

Singh, H .

EMBO JOURNAL, 1998, 17 (15) :4456-4468

← 1 2 3 4 5 6 7 →