Pharmaceutical processing with supercritical carbon dioxide

被引:357
作者
Subramaniam, B [1 ]
Rajewski, RA [1 ]
Snavely, K [1 ]
机构
[1] UNIV KANSAS, CTR DRUG DELIVERY RES, HIGUCHI BIOSCI CTR, LAWRENCE, KS 66045 USA
关键词
D O I
10.1021/js9700661
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Replacement of traditional solvents with ''environmentally benign'' carbon dioxide is receiving increased attention in pharmaceutical processing. Among the reported applications, particle formation with dense carbon dioxide and the ''clean'' synthesis of drug compounds using carbon dioxide as a reaction medium hold immense potential for large-scale application in the pharmaceutical industry. This paper provides-an overview of these rapidly emerging technologies along with examples of the wide variety of relatively contaminant-free pharmaceutical compounds that have been processed via these technologies on a laboratory scale. Challenges facing successful implementation in practice include demonstration of continuous production' and harvesting of particles with desired and reproducible product characteristics. Mathematical models aimed at a better fundamental understanding of the underlying thermophysical phenomena are essential for rational design and scale-up of these technologies.
引用
收藏
页码:885 / 890
页数:6
相关论文
共 54 条
[1]   FROM POTENTIAL TO PRACTICE - RELEVANT INDUSTRIAL APPLICATIONS OF PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY [J].
ANTON, K ;
BACH, M ;
BERGER, C ;
WALCH, F ;
JACCARD, G ;
CARLIER, Y .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1994, 32 (10) :430-438
[2]  
Berends E.M., 1994, P 3 INT S SUP FLUIDS, V3, p[337, 4087]
[3]   Formation of biocompatible polymer microspheres for controlled drug delivery by a supercritical antisolvent technique [J].
Bertucco, A ;
Pallado, P ;
Benedetti, L .
HIGH PRESSURE CHEMICAL ENGINEERING, 1996, 12 :217-222
[4]   Production of drug loaded microparticles by the use of supercritical gases with the aerosol solvent extraction system (ASES) process [J].
Bleich, J ;
Muller, BW .
JOURNAL OF MICROENCAPSULATION, 1996, 13 (02) :131-139
[5]   POLYMERIC MICROSPHERES PREPARED BY SPRAYING INTO COMPRESSED CARBON-DIOXIDE [J].
BODMEIER, R ;
WANG, H ;
DIXON, DJ ;
MAWSON, S ;
JOHNSTON, KP .
PHARMACEUTICAL RESEARCH, 1995, 12 (08) :1211-1217
[6]  
DEBENEDETTI PG, 1994, NATO ADV SCI INST SE, V273, P719
[7]   DISPERSION POLYMERIZATIONS IN SUPERCRITICAL CARBON-DIOXIDE [J].
DESIMONE, JM ;
MAURY, EE ;
MENCELOGLU, YZ ;
MCCLAIN, JB ;
ROMACK, TJ ;
COMBES, JR .
SCIENCE, 1994, 265 (5170) :356-359
[8]   POLYMERIC MATERIALS FORMED BY PRECIPITATION WITH A COMPRESSED FLUID ANTISOLVENT [J].
DIXON, DJ ;
JOHNSTON, KP ;
BODMEIER, RA .
AICHE JOURNAL, 1993, 39 (01) :127-139
[9]  
DONSI G, 1991, PHARM ACTA HELV, V66, P170
[10]   Extraction of spray-particles with supercritical fluids [J].
Eggers, R ;
Wagner, H ;
Jaeger, P .
HIGH PRESSURE CHEMICAL ENGINEERING, 1996, 12 :247-252