Pharmaceutical processing with supercritical carbon dioxide

被引:357
作者
Subramaniam, B [1 ]
Rajewski, RA [1 ]
Snavely, K [1 ]
机构
[1] UNIV KANSAS, CTR DRUG DELIVERY RES, HIGUCHI BIOSCI CTR, LAWRENCE, KS 66045 USA
关键词
D O I
10.1021/js9700661
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Replacement of traditional solvents with ''environmentally benign'' carbon dioxide is receiving increased attention in pharmaceutical processing. Among the reported applications, particle formation with dense carbon dioxide and the ''clean'' synthesis of drug compounds using carbon dioxide as a reaction medium hold immense potential for large-scale application in the pharmaceutical industry. This paper provides-an overview of these rapidly emerging technologies along with examples of the wide variety of relatively contaminant-free pharmaceutical compounds that have been processed via these technologies on a laboratory scale. Challenges facing successful implementation in practice include demonstration of continuous production' and harvesting of particles with desired and reproducible product characteristics. Mathematical models aimed at a better fundamental understanding of the underlying thermophysical phenomena are essential for rational design and scale-up of these technologies.
引用
收藏
页码:885 / 890
页数:6
相关论文
共 54 条
[21]   EVALUATION OF SUPERCRITICAL FLUID EXTRACTION IN THE PHARMACEUTICAL-INDUSTRY [J].
LARSON, KA ;
KING, ML .
BIOTECHNOLOGY PROGRESS, 1986, 2 (02) :73-82
[22]   EFFECT OF RESS DYNAMICS ON POLYMER MORPHOLOGY [J].
LELE, AK ;
SHINE, AD .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1994, 33 (06) :1476-1485
[23]   MORPHOLOGY OF POLYMERS PRECIPITATED FROM A SUPERCRITICAL SOLVENT [J].
LELE, AK ;
SHINE, AD .
AICHE JOURNAL, 1992, 38 (05) :742-752
[24]   Solubility of anti-inflammatory drugs in supercritical carbon dioxide [J].
Macnaughton, SJ ;
Kikic, I ;
Foster, NR ;
Alessi, P ;
Cortesi, A ;
Colombo, I .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1996, 41 (05) :1083-1086
[25]   RAPID EXPANSION OF SUPERCRITICAL FLUID SOLUTIONS - SOLUTE FORMATION OF POWDERS, THIN-FILMS, AND FIBERS [J].
MATSON, DW ;
FULTON, JL ;
PETERSEN, RC ;
SMITH, RD .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1987, 26 (11) :2298-2306
[26]   Design of nonionic surfactants for supercritical carbon dioxide [J].
McClain, JB ;
Betts, DE ;
Canelas, DA ;
Samulski, ET ;
DeSimone, JM ;
Londono, JD ;
Cochran, HD ;
Wignall, GD ;
ChilluraMartino, D ;
Triolo, R .
SCIENCE, 1996, 274 (5295) :2049-2052
[27]  
McHugh MA., 1994, SUPERCRITICAL FLUID, V2nd
[28]  
MOHAMED RS, 1989, ACS SYM SER, V406, P334
[29]  
MULLER BW, 1989, Patent No. 3744329
[30]  
Ohgaki IC, 1990, J SUPERCRIT FLUID, V3, P103, DOI 10.1016/0896-8446(90)90033-I