Formation of morphogen gradients in the Drosophila wing

被引：92

作者：

Strigini, M ^{[1
]}

Cohen, SM ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 03期

关键词：

Drosophila; morphogen; Hedgehog; Dpp; Wingless;

D O I：

10.1006/scdb.1999.0293

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Patterning of multicellular fields requires mechanisms to coordinate developmental decisions made by populations of cells. Evidence is accumulating that the necessary information is provided by localized sources of secreted signalling proteins which act as morphogens. We review evidence that Wingless, Dpp and Hedgehog proteins act as morphogens in the developing wing of Drosophila and discuss recent work illustrating that signalling helps to shape their activity gradients by regulating ligand distribution and by modulating the responsiveness of target cells. These studies suggest that there is more to Being a morphogen than formation of a ligand gradient by passive diffusion.

引用

页码：335 / 344

页数：10

共 72 条

[1] The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].