Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

被引：367

作者：

Cardona, K

Korbutt, GS

Milas, Z

Lyon, J

Cano, J

Jiang, W

Bello-Laborn, H

Hacquoil, B

Strobert, E

Gangappa, S

Weber, CJ

Pearson, TC

Rajotte, RV ^{[1
]}

Larsen, CP

机构：

[1] Univ Alberta, Surg Med Res Inst, Dent Pharm Ctr 1074, Edmonton, AB T6G 2N8, Canada

[2] Emory Univ, Sch Med, Emory Transplant Ctr, Dept Surg, Atlanta, GA 30322 USA

[3] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 03期

关键词：

D O I：

10.1038/nm1375

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence ( median survival, > 140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.

引用

页码：304 / 306

页数：3

共 14 条

[1] Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival [J].

Adams, AB ;

Shirasugi, N ;

Jones, TR ;

Durham, MM ;

Strobert, EA ;

Cowan, S ;

Rees, P ;

Hendrix, R ;

Price, K ;

Kenyon, NS ;

Hagerty, D ;

Townsend, R ;

Hollenbaugh, D ;

Pearson, TC ;

Larsen, CP .

JOURNAL OF IMMUNOLOGY, 2005, 174 (01) :542-550

[2] Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression [J].

Adams, AB ;

Durham, MM ;

Kean, L ;

Shirasugi, N ;

Ha, JW ;

Williams, MA ;

Rees, PA ;

Cheung, MC ;

Mittelstaedt, S ;

Bingaman, AW ;

Archer, DR ;

Pearson, TC ;

Waller, EK ;

Larsen, CP .

JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :1103-1111

[3] Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates [J].

Adams, AB ;

Shirasugi, N ;

Durham, MM ;

Strobert, E ;

Anderson, D ;

Rees, P ;

Cowan, S ;

Xu, HY ;

Blinder, Y ;

Cheung, M ;

Hollenbaugh, D ;

Kenyon, NS ;

Pearson, TC ;

Larsen, CP .

DIABETES, 2002, 51 (02) :265-270

[4] Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys [J].

Chen, G ;

Qian, H ;

Starz, T ;

Sun, HT ;

Garcia, B ;

Wang, XM ;

Wise, Y ;

Liu, YQ ;

Xiang, Y ;

Copeman, L ;

Liu, WH ;

Jevnikar, A ;

Wall, W ;

Cooper, DKC ;

Murase, N ;

Dai, YF ;

Wang, WY ;

Xiong, YL ;

White, DJ ;

Zhong, R .

NATURE MEDICINE, 2005, 11 (12) :1295-1298

[5]

COLLINS BH, 1995, J IMMUNOL, V154, P5500

[6] INTERACTION OF THE NATURAL ANTI-GAL ANTIBODY WITH ALPHA-GALACTOSYL EPITOPES - A MAJOR OBSTACLE FOR XENOTRANSPLANTATION IN HUMANS [J].

GALILI, U .

IMMUNOLOGY TODAY, 1993, 14 (10) :480-482

[7]

Kawai T, 2000, NAT MED, V6, P114, DOI 10.1038/72162

[8] Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets [J].

Kin, T ;

Korbutt, GS ;

Kobayashi, T ;

Dufour, JM ;

Rajotte, RV .

DIABETES, 2005, 54 (04) :1032-1039

[9] Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection [J].

Kirchhof, N ;

Shibata, S ;

Wijkstrom, M ;

Kulick, DM ;

Salerno, CT ;

Clemmings, SM ;

Heremans, Y ;

Galili, U ;

Sutherland, DER ;

Dalmasso, AP ;

Hering, BJ .

XENOTRANSPLANTATION, 2004, 11 (05) :396-407

[10] Large scale isolation, growth, and function of porcine neonatal islet cells [J].

Korbutt, GS ;

Elliott, JF ;

Ao, ZL ;

Smith, DK ;

Warnock, GL ;

Rajotte, RV .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (09) :2119-2129

← 1 2 →