A short, facile synthesis of 2-amino-1,5-dihydro-4H-pyrrolo[3,2-d]-pyrimidin-4-one (9-deazaguanine)

被引：18

作者：

Elliott, AJ ^{[1
]}

Montgomery, JA ^{[1
]}

Walsh, DA ^{[1
]}

机构：

[1] BIOCRYST PHARMACEUT INC,BIRMINGHAM,AL 35244

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期

关键词：

D O I：

10.1016/0040-4039(96)00840-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

9-Deazaguanine has been synthesized in four steps in an overall isolated yield of 18% from ethyl (ethoxymethylene)cyanoacetate and diethyl aminomalonate. Copyright (C) 1996 Elsevier Science Ltd.

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收藏

页码：4339 / 4340

页数：2

相关论文

共 8 条

[1] IMAI K, 1964, CHEM PHARM BULL, V12, P1030
[2] IMPROVED METHOD FOR THE PREPARATION OF GUANIDINES
KIM, KS
QIAN, LG
[J]. TETRAHEDRON LETTERS, 1993, 34 (48) : 7677 - 7680
[3] KLINE RS, 1978, J ORG CHEM, V43, P2536
[4] SYNTHESIS, TUBULIN BINDING, ANTINEOPLASTIC EVALUATION, AND STRUCTURE ACTIVITY RELATIONSHIP OF ONCODAZOLE ANALOGS
KRUSE, LI
LADD, DL
HARRSCH, PB
MCCABE, FL
MONG, SM
FAUCETTE, L
JOHNSON, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) : 409 - 417
[5] Montgomery J. A., 1993, Drugs of the Future, V18, P887
[6] STRUCTURE-BASED DESIGN OF INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE .1. 9-(ARYLMETHYL) DERIVATIVES OF 9-DEAZAGUANINE
MONTGOMERY, JA
NIWAS, S
ROSE, JD
SECRIST, JA
BABU, YS
BUGG, CE
ERION, MD
GUIDA, WC
EALICK, SE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) : 55 - 69
[7] TANAKA K, 1964, CHEM PHARM BULL, V12, P1024
[8] AN EXPEDITIOUS SYNTHESIS OF 2-AMINO-4(3H)-OXO-5H-PYRROLO[3,2-D]PYRIMIDINE (9-DEAZAGUANINE)
TAYLOR, EC
YOUNG, WB
WARD, CC
[J]. TETRAHEDRON LETTERS, 1993, 34 (29) : 4595 - 4598