Organocatalytic direct Michael reaction of ketones and aldehydes with β-nitrostyrene in brine

被引：434

作者：

Mase, N

Watanabe, K

Yoda, H

Takabe, K

Tanaka, F

Barbas, CF

机构：

[1] Shizuoka Univ, Fac Engn, Dept Mol Sci, Hamamatsu, Shizuoka 4328561, Japan

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 15期

关键词：

D O I：

10.1021/ja060338e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a direct, asymmetric Michael reaction that can be performed in brine or seawater without addition of organic solvents. A bifunctional catalyst with long hydrophobic alkyl chains efficiently catalyzed Michael reactions and afforded the desired products in excellent yield with high enantiomeric excess, even when only an equal molar ratio of the donor to acceptor was used. Copyright © 2006 American Chemical Society.

引用

页码：4966 / 4967

页数：2

共 22 条

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