Does the season or month of birth influence disease progression in multiple sclerosis?

被引：19

作者：

Tremlett, Helen L. ^{[1
]}

Devonshire, Virginia A. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Med, Vancouver, BC V6T 2B5, Canada

来源：

NEUROEPIDEMIOLOGY | 2006年 / 26卷 / 04期

关键词：

multiple sclerosis progression; seasonal variation; month of birth; survival analysis;

D O I：

10.1159/000092406

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We investigated the influence of season and birth month on sustained progression to Expanded Disability Status Scale 6 (requires a cane) through a database review of 2,319 definite multiple sclerosis (MS) patients followed for a mean 19.3 years, until July 2003 in British Columbia, Canada. The season of birth had a marginal effect on disease progression (p = 0.051), with winter babies exhibiting the slowest progression (p = 0.048). Birth month had a significant effect on progression (p = 0.038), mainly due to those January born having a 40% (95% CI 32.9-47.4) chance of requiring a cane later than those born in other months. There was some evidence to suggest that the gestational period had a small but long-lasting effect on later disease progression in British Columbia, Canada. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：195 / 198

页数：4

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