Reconstruction of biochemical networks in microorganisms

被引：621

作者：

Feist, Adam M. ^{[1
]}

Herrgard, Markus J. ^{[1
,2
]}

Thiele, Ines ^{[1
]}

Reed, Jennie L. ^{[3
]}

Palsson, Bernhard O. ^{[1
,4
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Synthet Genom, La Jolla, CA 92037 USA

[3] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA

[4] Univ Iceland, Ctr Syst Biol, IS-101 Reykjavik, Iceland

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SMALL NONCODING RNAS; ESCHERICHIA-COLI METABOLISM; TRANSCRIPTION FACTOR; SYSTEMS-APPROACH; GENE-EXPRESSION; IN-VITRO; SACCHAROMYCES-CEREVISIAE; PLASMODIUM-FALCIPARUM; BIOMASS COMPOSITION; HIGH-THROUGHPUT;

D O I：

10.1038/nrmicro1949

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Systems analysis of metabolic and growth functions in microbial organisms is rapidly developing and maturing. Such studies are enabled by reconstruction, at the genomic scale, of the biochemical reaction networks that underlie cellular processes. The network reconstruction process is organism specific and is based on an annotated genome sequence, high-throughput network-wide data sets and bibliomic data on the detailed properties of individual network components. Here we describe the process that is currently used to achieve comprehensive network reconstructions and discuss how these reconstructions are curated and validated. This Review should aid the growing number of researchers who are carrying out reconstructions for particular target organisms.

引用

页码：129 / 143

页数：15

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