Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN and stoichiometric amount of HCN

被引：69

作者：

Kato, N

Suzuki, M

Kanai, M

Shibasaki, M

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Japan Sci & Technol Corp, PRESTO, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 15期

基金：

日本学术振兴会;

关键词：

asymmetric catalysis; Strecker reaction; ketoimines; disubstituted amino acids; atom economy;

D O I：

10.1016/j.tetlet.2004.02.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalyst loading as low as 0.1 mol% was achieved in the enantioselective Strecker reaction of ketoimines. Excellent enantioselectivity was obtained with a combined use of a catalytic amount of TMSCN and a stoichiometric amount of HCN as a reagent, and a chiral gadolinium complex as a catalyst. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3153 / 3155

页数：3