Synthesis of Bioactive Natural Polymethoxyflavones and Their Vinyl Ether Derivatives

被引：9

作者：

Cai Shuang-lian ^{[1
]}

Liu Shuang ^{[1
]}

Liu Li ^{[1
]}

Wang Qiu-an ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2012年 / 28卷 / 04期

关键词：

Flavonoid; Polymethoxyflavone; Prenylation; Farnesylation; INHIBITION; FLAVONES; CITRUS; NOBILETIN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Bioactive natural polymethoxyflavones 1-6 and their vinyl ether derivatives 7-15 were synthesized by bromination, aromatic nucleophilic substitution, methylation, benzyl protection, Friedel-Crafts acetylation, aldol condensation, cyclization, DDQ dehydrogenation, regioselective demethylation, debenzylation and O-prenylation or O-farnesylation with resorcinol and appropriate substituted benzaldehydes as starting materials. Among them, compounds 7-15 are new compounds. Natural products 2-4 were firstly total synthesized. The syntheses of compounds 1, 5 and 6 were efficiently improved by the new synthetic routes. The structures of all synthetic compounds were confirmed by NMR, IR spectra and MS.

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收藏

页码：631 / 636

页数：6

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