Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography

被引：20

作者：

Li, You Leo ^{[1
,2
]}

Seekell, Kevin ^{[1
,2
]}

Yuan, Hsiangkuo ^{[1
,2
]}

Robles, Francisco E. ^{[3
]}

Wax, Adam ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Fitzpatrick Inst Photon, Durham, NC 27708 USA

[3] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 08期

基金：

美国国家卫生研究院;

关键词：

GOLD NANORODS; RECEPTOR;

D O I：

10.1364/BOE.3.001914

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

We have recently developed a novel dual window scheme for processing spectroscopic OCT images to provide spatially resolved true color imaging of chromophores in scattering samples. Here we apply this method to measure the extinction spectra of plasmonic nanoparticles at various concentrations for potential in vivo applications. We experimentally demonstrate sub-nanomolar sensitivity in the measurement of nanoparticle concentrations, and show that colorimetric imaging with multiple species of nanoparticles produces enhanced contrast for spectroscopic OCT in both tissue phantom and cell studies. (C) 2012 Optical Society of America

引用

页码：1914 / 1923

页数：10

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