Bromotyrosine-derived metabolites from the sponge Aiolochroia crassa

被引：35

作者：

Gao, HF

Kelly, M

Hamann, MT ^{[1
]}

机构：

[1] Univ Mississippi, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Nat Ctr Dev Nat Prod, University, MS 38677 USA

[3] UNITEC Inst Technol, Fac Hlth Sci & Technol, Auckland, New Zealand

来源：

TETRAHEDRON | 1999年 / 55卷 / 32期

关键词：

antibiotics; marine metabolites; spiro compounds;

D O I：

10.1016/S0040-4020(99)00553-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemical investigation of secondary metabolites from the sponge Aiolochroia crassa has been performed and five bromotyrosine derivatives (1-5) were identified. Their structures have been assigned on the basis of spectroscopic analysis, of which araplysillin III (2) and hexadellin C (3) possess new structures. The absolute configurations of dibromotyrosine moieties of 2 were determined by HPLC analysis of derivatized constituent amino acids obtained from acid hydrolysis. The stereochemistry of the spirocyclohexadienylisoxazoline moiety of compounds 1-3 was deduced from spectroscopic comparison of the same moiety of aerothionin, of which the absolute configuration was previously assigned by X-ray and CD analysis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：9717 / 9726

页数：10

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