Mechanism, Function and Regulation of Microtubule-Dependent Microtubule Amplification in Mitosis

被引：11

作者：

Zhu, Hui ^{[1
]}

Fang, Kayleen ^{[1
]}

Fang, Guowei ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

[2] Genentech Inc, San Francisco, CA 94080 USA

来源：

MOLECULES AND CELLS | 2009年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Plk1; FAM29A; NEDD1; microtubule amplification; microtubule nucleation; mitotic spindle; POLO-LIKE KINASES; GAMMA-TUBULIN; MITOTIC SPINDLE; CELL-DIVISION; RECRUITMENT; NUCLEATION; COMPLEX; CENTROSOME;

D O I：

10.1007/s10059-009-0014-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitotic spindle mediates the segregation of chromosomes in the cell cycle and the proper function of the spindle is crucial to the high fidelity of chromosome segregation and to the stability of the genome. Nucleation of microtubules (MTs) from centrosomes and chromatin represents two well-characterized pathways essential for the assembly of a dynamic spindle in mitosis. Recently, we identified a third MT nucleation pathway, in which existing MTs in the spindle act as a template to promote the nucleation and polymerization of MTs, thereby efficiently amplifying MTs in the spindle. We will review here our current understanding on the molecular mechanism, the physiological function and the cell-cycle regulation of MT amplification.

引用

页码：1 / 3

页数：3

共 16 条

[1] Polo-like kinases and the orchestration of cell division [J].