Reconstruction of genetic circuits

被引：249

作者：

Sprinzak, D

Elowitz, MB ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] CALTECH, Dept Appl Phys, Pasadena, CA 91125 USA

来源：

NATURE | 2005年 / 438卷 / 7067期

关键词：

D O I：

10.1038/nature04335

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach: one can construct and analyse synthetic genetic circuits based on their natural counterparts. Such synthetic circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit. Here we describe recent progress in this area of synthetic biology, highlighting newly developed genetic components and biological lessons learned from this approach.

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收藏

页码：443 / 448

页数：6

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