Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress

被引：108

作者：

Hammack, SE

Richey, KJ

Watkins, LR

Maier, SF

机构：

[1] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA

[2] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

[3] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2004年 / 118卷 / 02期

关键词：

D O I：

10.1037/0735-7044.118.2.443

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Uncontrollable or inescapable shock (IS) produces behavioral changes that are characterized by a sensitized fear system and a deficit in fight-flight responding. These behavioral changes have been argued to represent an anxiety-like state produced by the uncontrollability of the stressor. The bed nucleus of the stria terminalis (BNST) has been implicated in the mediation of long-duration responses to unpredictable stressors, which have also been argued to represent anxiety. In the present study, the effects of BNST chemical lesion on the IS-induced sensitization of freezing to an environment previously paired with shock and the IS-induced impairment of escape responding were investigated. BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS.

引用

页码：443 / 448

页数：6

共 65 条

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