Addition of nucleophiles to 6-vinylpurines

被引：25

作者：

Overas, AT

Bakkestuen, AK

Gundersen, LL

Rise, F

机构：

[1] UNIV OSLO,DEPT CHEM,N-0315 OSLO,NORWAY

[2] UNIV OSLO,DEPT PHARM,N-0316 OSLO,NORWAY

来源：

ACTA CHEMICA SCANDINAVICA | 1997年 / 51卷 / 11期

关键词：

D O I：

10.3891/acta.chem.scand.51-1116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.

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页码：1116 / 1124

页数：9

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