Regiochemistry in addition of Grignard reagents to N,N'-dibenzylated 2-purinones

被引：11

作者：

Andresen, G

Gundersen, LL

Rise, F

机构：

[1] Department of Chemistry, University of Oslo, N-0315 Oslo, P. O. Box 1033, Blindern

来源：

TETRAHEDRON | 1996年 / 52卷 / 40期

关键词：

D O I：

10.1016/0040-4020(96)00779-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,3-, 1,7-,1,9- and 3,7-dibenzylpurin-2-one form stable adducts when reacted with Grignard reagents. Reaction took place in the purine 6- or 8-position, and substantial differences in the regiochemical outcome of the reactions were found among the isomers. Several new classes of purinones are described here for the first time. The structure elucidations of the products were accomplished by HETCOR, COLOC, GA-HMQC and GA-HMBC NMR spectroscopy. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：12979 / 12992

页数：14

共 53 条

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