Continuous Processing and Efficient in Situ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

被引：36

作者：

Ahmed-Omer, Batool ^{[1
]}

Sliwinski, Eric ^{[1
]}

Cerroti, John P. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

[2] Magritek GmbH, Gebaude VO Bldg VO,Triwo Technopk Aachen, D-52068 Aachen, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2016年 / 20卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

ONLINE IR ANALYSIS; ALPHA-AMINO-ACIDS; ULTRAFAST 2D NMR; MICROFLUIDIC SYSTEM; CHEMICAL-SYNTHESIS; ORGANIC-SYNTHESIS; IODONIUM YLIDES; OPTIMIZATION; REAGENTS; SPECTROMETER;

D O I：

10.1021/acs.oprd.6b00177

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Real-time NMR spectroscopy has proven to be a rapid and an effective monitoring tool to study the hypervalent iodine(III) mediated cyclopropanation. With the ever increasing number of new synthetic methods for carbon-carbon bond formation, the NMR in situ monitoring of reactions is becoming a highly desirable enabling method. In this study, we have demonstrated the versatility of benchtop NMR using inline and online real-time monitoring methods to access mutually complementary information for process understanding, and we developed new approaches for real-time monitoring addressing challenges associated with better integration into continuous processes.

引用

页码：1603 / 1614

页数：12

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