ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

被引：210

作者：

Carter, Catherine F. ^{[1
]}

Lange, Heiko ^{[1
]}

Ley, Steven V. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Wittkamp, Brian ^{[2
]}

Goode, Jon G. ^{[3
]}

Gaunt, Nigel L. ^{[3
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Mettler Toledo AutoChem, Columbia, MD 21046 USA

[3] Mettler Toledo AutoChem UK, Leicester LE4 1AW, Leics, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

SUPERCRITICAL FLUIDS; MULTISTEP SYNTHESIS; CHEMISTRY; REAGENTS; REDUCTION; PRODUCT; SUZUKI; BATCH;

D O I：

10.1021/op900305v

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous How chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.

引用

页码：393 / 404

页数：12

共 62 条

[1] ARMOUR MA, 2003, HAZARDOUS LAB CHEM D, P461
[2] PREPARATIVE-SCALE ORGANOMETALLIC CHEMISTRY IN SUPERCRITICAL FLUIDS - ISOLATION OF [CR(CO)5(C2H4)] AS A STABLE SOLID AT ROOM-TEMPERATURE
BANISTER, JA
HOWDLE, SM
POLIAKOFF, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (24) : 1814 - 1815
[3] The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor
Baumann, Marcus
Baxendale, Ian R.
Ley, Steven V.
[J]. SYNLETT, 2008, (14) : 2111 - 2114
[4] Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Baumann, Marcus
Baxendale, Ian R.
Ley, Steven V.
Nikbin, Nikzad
Smith, Christopher D.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (09) : 1587 - 1593
[5] A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Baumann, Marcus
Baxendale, Ian R.
Ley, Steven V.
Nikbin, Nikzad
Smith, Christopher D.
Tierney, Jason P.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (09) : 1577 - 1586
[6] Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
Baumann, Marcus
Baxendale, Ian R.
Ley, Steven V.
Smith, Christoper D.
Tranmer, Geoffrey K.
[J]. ORGANIC LETTERS, 2006, 8 (23) : 5231 - 5234
[7] Development of fluorination methods using continuous-flow microreactors
Baumann, Marcus
Baxendale, Ian R.
Martin, Laetitia J.
Ley, Steven V.
[J]. TETRAHEDRON, 2009, 65 (33) : 6611 - 6625
[8] A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Baxendale, Ian R.
Deeley, Jon
Griffiths-Jones, Charlotte M.
Ley, Steven V.
Saaby, Steen
Tranmer, Geoffrey K.
[J]. CHEMICAL COMMUNICATIONS, 2006, (24) : 2566 - 2568
[9] Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-Ones and Their Use in Heterocycle Synthesis
Baxendale, Ian R.
Schou, Soren C.
Sedelmeier, Joerg
Ley, Steven V.
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (01) : 89 - 94
[10] Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Baxendale, Ian R.
Ley, Steven V.
Mansfield, Andrew C.
Smith, Christopher D.
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (22) : 4017 - 4021

← 1 2 3 4 5 6 7 →