Role of integrins in peripheral nerves and hereditary neuropathies

被引：37

作者：

Berti, Caterina ^{[1
]}

Nodari, Alessandro ^{[1
]}

Wrabetz, Lawrence ^{[1
]}

Feltri, Maria Laura ^{[1
]}

机构：

[1] Ist Sci San Raffaele, DIBIT, I-20132 Milan, Italy

来源：

NEUROMOLECULAR MEDICINE | 2006年 / 8卷 / 1-2期

关键词：

laminin; integrins; Schwann cell; MDC1A; conditional mutagenesis;

D O I：

10.1385/NMM:8:1:191

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interactions between Schwann cells and extracellular matrix on one surface, and axons on the other, are required for correct myelination in the developing peripheral nervous system. Integrins are transmembrane proteins that mediate the former in association with other surface receptors. This review focuses on the role that integrins play in the development of the peripheral nervous system, and in inherited human peripheral neuropathies. Here we describe recent findings on integrin signaling to different intracellular pathways, focusing on cell adhesion, migration, and polarization. Then we use information derived from recent experiments of targeted mutagenesis in mice to show that, consistent with temporally regulated expression, different integrins serve multiple roles in developing nerve.

引用

页码：191 / 204

页数：14

共 102 条

[31] Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier [J].